The Directorate of Science & Technology, Govt. of Mizoram is the main administrative office of Science and Technology in Mizoram. It was created as a Cell in the year 1986 with a view to utilise Science & Technology inputs for various developmental activities and to take up scientific projects and schemes pertaining to frontier areas of Science. Its status as a Wing under the Planning & Programme Implementation Department was upgraded to the Directorate on 30 August, 2011.

At present, there are three autonomous bodies functioning under the aegis of the Directorate of Science & Technology viz., Mizoram Science, Technology and Innovation Council (MISTIC), Mizoram Remote Sensing Application Centre (MIRSAC) and Mizoram Science Centre(MSC). The Directorate also houses several centres which play specific role for science and technology promotion and popularisation in various fields such as the State Meteorological Centre, Patent Information Centre and State Climate Change Cell. Besides these Centre, the Directorate also acts as a nodal department for the National Informatics Centre (NIC).